The activity of a heat labile variant of Regan type alkaline phosphatase (HLRI) was studied in the serum of 38 histologically proved patients with Hodgkin's disease. The activity was also studied in 40 normal healthy adults matched for age and sex as control. HLRI was significantly elevated in patie
Dowling–Degos disease——A heat aggravated variant
✍ Scribed by Steven Kossard; Joseph Krivanek
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 221 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0004-8380
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✦ Synopsis
SUMMARY
A 22‐year‐old woman presented with a 5‐year history of a micropapular eruption localized to the flexor aspect of her limbs as well as persistent reticulate pigmentation of her neck and upper chest resembling Darier’s disease. The eruption was associated with pruritus that was precipitated by heat and was worse in summer. The axillae, groins and inframammary areas had multiple papules but lacked reticulate pigmentation. Multiple biopsies showed an epidermis with club‐ and antler‐like rete ridges but no acantholysis or dyskeratosis. This distinct clinical presentation may represent an unusual heat aggravated variant of Dowling–Degos disease that clinically shares features with Darier’s disease and transient acantholytic dermatosis.
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