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Double-stranded RNA regulation of DNA synthesis in fibroblasts

โœ Scribed by Michael A. Perricone; Shri N. Giri; Dallas M. Hyde

Book ID
115892696
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
765 KB
Volume
198
Category
Article
ISSN
0014-4827

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The synthetic double-stranded RNA polyinosinate-polycytidylate [poly(I).poly(C)] was mitogenic in cultures of human foreskin fibroblasts, as demonstrated by a stimulation of 3H-thymidine incorporation and an increase in cell density. Poly(I).poly(C) is a potent inducer of interferon (IFN)-beta in hu