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Double strand cleavage of genomic DNA at a single site by triple helix formation

✍ Scribed by Strobel, Scott A.; Moser, Heinz E.; Dervan, Peter B.

Book ID
125526055
Publisher
American Chemical Society
Year
1988
Tongue
English
Weight
822 KB
Volume
110
Category
Article
ISSN
0002-7863

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## Abstract __Oligonucleotide‐directed triple‐helix formation provides a rational means to interfere with genomic DNA targets and to direct modifications at specific sites. We have developed a new class of compounds that, at low concentrations, efficiently targets and damages double‐stranded DNA sp