✦ LIBER ✦

Double metal-catalyzed cross-coupling reactions of alkenyl Sulfoximines with diorganozinc reagents: Stereoselective synthesis of a key optically active 3-Oxa-Carbacyclin intermediate

✍ Scribed by Hans-Joachim Gais; Gerd Bülow

Publisher: Elsevier Science
Year: 1992
Tongue: French
Weight: 277 KB
Volume: 33
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)93969-8

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✦ Synopsis

A stereoselective synthesw of the d&stereo-and enanUomerically pure 3-0~~~ carbacyclfn intermediate 2b from ketone 3 has been accomplished based on the Tamao-Kumada methodology Nickeland magnesium-catalyzed cross-couplmg reaction of the alkenyl sulfoximfne 5 with the pure diorganozinc reagent 6a led to the blcychc allylic stlane 7a and Its 2 isomer In a ratio of 99 1 Both were oxtdlzed to the allyllc alcohol 8 and its Z

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Double metal-catalyzed cross-coupling re

Double metal-catalyzed cross-coupling reactions of alkenyl sulfoximines with diorganozinc reagents: Synthesis of optically active axial chiral allylic silanes

✍ Hans-Joachim Gais; Gred Bülow 📂 Article 📅 1992 🏛 Elsevier Science 🌐 French ⚖ 296 KB

## Nickel- and maqneslum-catalvzed cross-couplfns reaction of the alkenul sulfoximine 5 with the pure-diorganozinc-reagents