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Double immunocytochemical evidence for a clonal development of specific antibody-containing cells in the rabbit spleen

✍ Scribed by van Rooijen, N. ;Kors, N. ;van Nieuwmegen, R.

Publisher: John Wiley and Sons
Year: 1984
Tongue: English
Weight: 560 KB
Volume: 209
Category: Article
ISSN: 0003-276X
DOI: 10.1002/ar.1092090318

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✦ Synopsis

Rabbits were intravenously primed with the antigens human serum albumin (HSA) and bovine gamma globulin (BGG). The antigens were given simultaneously, or at an interval of 1, 2, or 4 days. After 2 months an intravenous booster injection with both antigens was given simultaneously. The localization pattern of anti-HSA-antibody-containing cells and of anti-BGG-antibody-containing cells in the spleen was determined during both the primary and secondary immune response. Anti-HSA-antibody-containing cells and anti-BGG-antibody-containing cells were not distributed randomly but, rather, were found in defined groups during the induction of a n immune response. The most probable explanation for this grouping is that lymphoid cells, once triggered to proliferation by a particular antigen, show a clonal development in the spleen. During their proliferation and successive antibody formation, they migrate only slowly, so that they remain close together. Specific-antibody-containing cells were also detected in the popliteal lymph nodes and in the appendix of the rabbits.

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