Double frameshift mutations in APC and MSH2 in the same individual
✍ Scribed by Claudio Soravia; Celia D. Delozier; Zuzana Dobbie; Claudine Rey Berthod; Eviano Arrigoni; Marie-Anne Bründler; Jean-Louis Blouin; William D. Foulkes; Pierre Hutter
- Book ID
- 106059299
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 45 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0179-1958
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Ministero dell'Università e della Ricerca Scientifica (MURST) COFIN99; Ministero della Sanità (Progetti Finalizzati) Communicated by Mark H. Paalman Hereditary nonpolyposis colorectal cancer (HNPCC) is caused by mutations of genes encoding for proteins of the mismatch repair (MMR) machinery. The maj
APC mutations introduce premature stop codons into the open reading frame of the gene, leading to the formation of truncated tumor suppressor proteins. Both RNA and protein levels are likely to be profoundly altered by such nonsense mutations. To test this hypothesis, Western blotting and RT-PCR str