𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Double frameshift mutations in APC and MSH2 in the same individual

✍ Scribed by Claudio Soravia; Celia D. Delozier; Zuzana Dobbie; Claudine Rey Berthod; Eviano Arrigoni; Marie-Anne Bründler; Jean-Louis Blouin; William D. Foulkes; Pierre Hutter


Book ID
106059299
Publisher
Springer
Year
2006
Tongue
English
Weight
45 KB
Volume
22
Category
Article
ISSN
0179-1958

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Four novel MSH2 and MLH1 frameshift muta
✍ Oana Caluseriu; Emanuela Lucci Cordisco; Alessandra Viel; Silvia Majore; Riccard 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 99 KB 👁 2 views

Ministero dell'Università e della Ricerca Scientifica (MURST) COFIN99; Ministero della Sanità (Progetti Finalizzati) Communicated by Mark H. Paalman Hereditary nonpolyposis colorectal cancer (HNPCC) is caused by mutations of genes encoding for proteins of the mismatch repair (MMR) machinery. The maj

Chain-terminating mutations in the APC g
✍ Viviana Gismondi; Paola Stagnaro; Simona Pedemonte; Roberta Biticchi; Silvano Pr 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 171 KB

APC mutations introduce premature stop codons into the open reading frame of the gene, leading to the formation of truncated tumor suppressor proteins. Both RNA and protein levels are likely to be profoundly altered by such nonsense mutations. To test this hypothesis, Western blotting and RT-PCR str