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Double dioxanone-to-dihydropyran reorganization. construction of a C(1)-C(13) erythronolide template.

✍ Scribed by Steven D. Burke; Kevin C. Lee; Dinos Santafianos


Publisher
Elsevier Science
Year
1991
Tongue
French
Weight
290 KB
Volume
32
Category
Article
ISSN
0040-4039

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The key synthons 2 and 3 [with suitable protecting groups] of the erythronolide A seco acid (1) have been prepared in an enantiomerically pure form, utilizing a stereoselective osmylation of chiral hydroxy (Z,E)-diene ester 6a and subsequent hydrogenation. Recent interest in macrolide and ionophore