Double Cyclization of Bis(α-hetarylmethyl)amino Esters to Optically Active Bridged N-Heterocycles of HIV-Inhibiting Activity.

Double Cyclization of Bis(α-hetarylmethy

Double Cyclization of Bis(α-hetarylmethyl)amino Esters to Optically Active Bridged N-Heterocycles of HIV-Inhibiting Activity

✍ Heike Faltz; Christoph Bender; Birgitta M. Wöhrl; Karin Vogel-Bachmayr; Ullrich 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 322 KB

## Abstract Anellated 1‐azabicyclo[3.3.1]nonanes **6** were synthesized by several routes starting from natural α‐amino esters **2** and __o__‐haloaryl‐ or __o__‐bromohetarylmethyl bromides **1**. __N__‐Alkylation of the starting amino esters to **5** and **3** was followed by halogen/lithium excha