“Double crush” in Parkinson's disease

✍ Scribed by Moran Weinberger; Rivka Inzelberg

• Book ID: 101465713
• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 46 KB
• Volume: 68
• Category: Article
• ISSN: 0364-5134
• DOI: 10.1002/ana.22260

✦ Synopsis

activates the hypothalamic-pituitary-adrenal (HPA) axis. 4 Several lines of evidence suggest that repeated exercise-induced activation of the HPA axis, such as in endurance-trained subjects, leads to HPA axis adaptation. 5 The ability of neuroactive steroids to reduce HPA axis activation may play an important role in homeostasis being re-established following stressful events. Considering that acute stress results in a rapid increase of neuroactive steroids to levels known to modulate GABA A receptor function, exercise as a positive stressor may beneficially affect the epileptic brain.

Based on the evidence presented, we postulate that the reduced seizure susceptibility after exercise programs observed in human and animal studies could also be attributed to neurosteroid regulation. On the whole, we would like to express our congratulations to Lawrence and colleagues 1 for their interesting paper and to highlight the possible role of exercise intervention in this context.