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Dosing protocol and analgesic efficacy determine opioid tolerance in the mouse

✍ Scribed by Priyanka A. Madia; Shveta V. Dighe; Sunil Sirohi; Ellen A. Walker; Byron C. Yoburn


Book ID
105882877
Publisher
Springer
Year
2009
Tongue
English
Weight
317 KB
Volume
207
Category
Article
ISSN
0033-3158

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Background. Development of tolerance to opioid analgesics occurs often in patients with cancer-related pain. Cross-tolerance among opioid analgesics provides the physician with a major management problem. Incomplete cross-tolerance among opioid analgesics has been demonstrated to occur in animals an