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Dose–Effect Functions for Cocaine Self-Administration: Effects of Schedule and Dosing Procedure

✍ Scribed by Glen M Sizemore; Teresa M Gaspard; Susy A Kim; Lois E Walker; Sheila L Vrana; Steven I Dworkin

Book ID
114103517
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
287 KB
Volume
57
Category
Article
ISSN
0091-3057

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✍ David C. S. Roberts; Elliot A. Loh; Gary Vickers 📂 Article 📅 1989 🏛 Springer 🌐 English ⚖ 414 KB

Intravenous cocaine self-administration behavior in rats was investigated using a progressive ratio (PR) schedule of reinforcement. The first response on the lever each day produced a drug infusion, whereupon the requirements of the schedule escalated with each reinforcement until the behavior extin