Dose response to inhaled terbutaline powder and peak inspiratory flow through Turbuhaler® in children with mild to moderate asthma

✍ Scribed by E. Ståhl; L. B. Ribeiro; G. Sandahl

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 494 KB
• Volume: 22
• Category: Article
• ISSN: 8755-6863
• DOI: 10.1002/(sici)1099-0496(199608)22:2<106::aid-ppul5>3.0.co;2-o

✦ Synopsis

The purpose of this study was to investigate the relative effectiveness of 0.25 mg, 0.5 mg, and 1 .O mg of terbutaline, administered via Turbuhalerm, in children with mild to moderate asthma, and to register peak inspiratoly flow rates through Turbuhalerm (PIFTBH). Thirty-seven children in Portugal (one center) and 45 children in Sweden (one center) aged 3-10 years participated in two separate, double-blind, placebo-controlled, crossover, and randomized studies of the same design. Because of differences in othertherapies for asthma and climate, combination of the two studies into one metanalysis did not appear appropriate. The children inhaled 0.25 mg, 0.5 mg, and 1 .O mg terbutaline sulfate and placebo t.i.d. for consecutive 2-week periods without washout periods. Peak expiratory flow rates (PEF) were measured at home before and 15 minutes after each inhalation in the morning, afternoon, and evening. Pl FTBH was measured twice at each of four clinic visits. At the Portuguese center the increases in mean morning PEF from before to after inhalation were 32 Umin after 0.25 mg, 35 Umin after 0.5 mg, and 40 Umin after 1.0 mg. The corresponding figures in Sweden were 26 Umin, 31 Umin, and 29 Umin after 0.25 mg, 0.5 mg, and 1 .O mg, respectively. For children 3-6 years, mean values for PIFTsH were 60 Umin in Portugal (n = 151, and 58 Urnin in Sweden (n = 23). In the 7-10 year group the mean Pl FTBH was 72 Umin ( n = 22) in Portugal, and 68 Umin ( n = 22) in Sweden. We conclude that inhalation of terbutaline sulfate via Turbuhaler" at a small dose of 0.25 mg resulted in good bronchodilation and was comparable to inhalations of 0.5 rng and 1.0 mg in children aged 3-10 years with mild to moderate asthma. Pl FTBH were comparable to values previously recorded in healthy 6-year-old and older children and in adult asthmatic patients.