Dose response studies: how do we make them conclusive?

✍ Scribed by Anders Källén; Per Larsson

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 121 KB
• Volume: 18
• Category: Article
• ISSN: 0277-6715
• DOI: 10.1002/(sici)1097-0258(19990330)18:6<629::aid-sim72>3.0.co;2-y

✦ Synopsis

In this paper we discuss how to make meaningful use of a dose response study. It is argued that concepts like the minimal effective dose are not clinically meaningful and that the purpose of a dose response study should be to identify the drug potency in relation to a known active control. We also discuss various ways of carrying out the analysis.