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Dose-Repetition Increases the Mutagenic Effectiveness of N-ethyl-N-nitrosourea in Mouse Spermatogonia

✍ Scribed by S. Hitotsumachi, D. A. Carpenter and W. L. Russell

Book ID
123632182
Publisher
National Academy of Sciences
Year
1985
Tongue
English
Weight
528 KB
Volume
82
Category
Article
ISSN
0027-8424

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The relationship between cell proliferation and mutagenesis can be investigated in vivo due to the advent of transgenic animal mutation assays. In these assays, slowly proliferating tissues, such as mammary gland and liver, that are exposed to mutagens generally have longer manifestation times for m