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Dose ratio between morphine and hydromorphone in patients with cancer pain: a retrospective study

✍ Scribed by Peter Lawlor; Kenneth Turner; John Hanson; Eduardo Bruera

Book ID
117479736
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
84 KB
Volume
72
Category
Article
ISSN
0304-3959

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## Background: Current equianalgesic reference tables, based largely on single dose studies, give dose ratios of 1:1 to 4:1 for oral morphine to oral methadone, which possibly are inaccurate in patients with cancer pain who are exposed to multiple doses of these opioids. the purpose of this study w

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## BACKGROUND. When a change of opioid is considered, equianalgesic dose tables are used. These tables generally propose a dose ratio of 5:l between morphine and hydromorphone. In the case of a change from subcutaneous hydromorphone to methadone, dose ratios ranging from 1:6 to 1:10 are proposed.