✦ LIBER ✦

Dose optimisation—the effect of age

✍ Scribed by Stephen H.D Jackson

Book ID: 117549558
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 181 KB
Volume: 1220
Category: Article
ISSN: 0531-5131
DOI: 10.1016/s0531-5131(01)00301-6

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## Abstract The effects of age and dose on the pharmacokinetics of ketoprofen were evaluated in young adult and senescent male Fischer 344 rats following intravenous administration of 2·5 and 10 mg kg^−1^. Plasma concentrations were measured by HPLC and free ketoprofen determined by equilibrium dia