𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Dose level effects of triazolam on sleep and response to a smoke detector alarm

✍ Scribed by L. C. Johnson; C. L. Spinweber; S. C. Webb; A. G. Muzet


Publisher
Springer
Year
1987
Tongue
English
Weight
705 KB
Volume
91
Category
Article
ISSN
0033-3158

No coin nor oath required. For personal study only.

✦ Synopsis


Thirty-six young adult, male subjects with sleep-onset insomnia were equally divided into placebo, 0.25 mg, and 0.5 mg triazolam groups to examine the effects of the hypnotic, with particular attention to dose level on efficacy, sleep stages, and awakening to a smoke detector alarm. On nights 1 and 4 of a five-consecutive-night protocol, a standard home smoke detector alarm was sounded during stage 2, 5 min after sleep onset, in slow wave sleep (SWS), and at the time of the early morning awakening. The alarm registered 78 dB SPL at the pillow. EEG arousal latency and reaction time to a button press were studied. Failure to awaken to three 1-min alarm presentations was scored as "no response." Both dose levels produced similar reductions in sleep latency, decreases in SWS, increases in stage 2, and increases in sleep efficiency. Both dose levels showed similar sedative effects to the smoke alarm. Fifty percent of triazolam subjects failed to awaken on night 1 during SWS, and EEG arousal and response latencies were significantly slowed. Some drug tolerance or sensitization to the alarm was seen by night 4. By morning, all subjects were easily awakened on both nights. The 0.25 mg dose is clearly an effective dose level for both sleep efficacy and sedative effects to outside noise, which in some instances could pose potential problems.


πŸ“œ SIMILAR VOLUMES


A comparison of the dose response effect
✍ M. Radulovacki; R. M. Virus; D. Rapoza; R. A. Crane πŸ“‚ Article πŸ“… 1985 πŸ› Springer 🌐 English βš– 475 KB

The dose-response effects of intracerebroventricular (ICV) infusion of the pyrimidine ribonucleosides cytidine and uridine and the purine ribonucleoside adenosine on sleep and wakefulness (W) in rats were examined and compared. All three drugs were administered at doses of 1,10, and 100 nmol in volu

Effect of salmeterol treatment on nitric
✍ Gunver Fuglsang; Jennifer Vikre-JΓΈrgensen; Lone Agertoft; SΓΈren Pedersen πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 111 KB πŸ‘ 2 views

The aim of this study was to investigate whether regular treatment with inhaled salmeterol modifies the dose-response curve to the inhaled short-acting beta2-agonist terbutaline or affects the concentration of nitric oxide (NO) in exhaled air of children with asthma. Twenty-two children aged 7 to 15