Functional COMT variant predicts respons
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Eng-King Tan; Sin-Yun Cheah; Stephanie Fook-Chong; Kenneth Yew; V.R. Chandran; S
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Article
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2005
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John Wiley and Sons
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English
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Pyridoxal-5-phosphate, the biological active form of pyridoxine, is a cofactor for dopa-decarboxylase (DDC) enzyme. Pyridoxine may augment the conversion of levodopa to dopamine in the periphery and therefore decrease availability of levodopa to the brain. However, this effect can be negated in the