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Dose-Finding with Two Agents in Phase I Oncology Trials

✍ Scribed by Peter F. Thall; Randall E. Millikan; Peter Mueller; Sang-Joon Lee

Book ID
110693697
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
221 KB
Volume
59
Category
Article
ISSN
0006-341X

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Most phase I trials in oncology use standard methods for treating successive groups of patients with increasing doses in order to determine the maximum tolerated dose (MTD). These methods have been criticized because they treat many patients at suboptimal dose levels, and do not provide an accurate