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Dose finding study of granisetron in patients receiving high-dose cisplatin chemotherapy

โœ Scribed by Riviere, A


Book ID
109836985
Publisher
Nature Publishing Group
Year
1994
Tongue
English
Weight
978 KB
Volume
69
Category
Article
ISSN
0007-0920

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โœ M. Soukop ๐Ÿ“‚ Article ๐Ÿ“… 1994 ๐Ÿ› Springer-Verlag ๐ŸŒ English โš– 663 KB

In this double-blind study, the efficacy and safety of a single intravenous dose of a novel antiemetic, granisetron, was assessed at two dose levels (40 ~g/kg and 160 Ixg/kg). A group of 355 patients were given prophylactic granisetron prior to receiving highdose cisplatin chemotherapy. In the first

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The object of the study was to determine whether dexamethasone improved the efficacy of the serotonin receptor (5-HT3) antagonist granisetron in controlling acute (within 24 h) emesis in cancer patients receiving high-dose cisplatin chemotherapy and to ascertain whether continuation of granisetron a