Dose-dependent localisation and potential for therapy of F(ab')2 fragments against CEA studied in a human tumour xenograft model

Monoclonal antibodies to placental alkal

Monoclonal antibodies to placental alkaline phosphatase: Preclinical evaluation in a human xenograft tumour model of F(ab')2 and Fab fragments

✍ H. Durbin; E. M. Milligan; S. J. Mather; D. F. Tucker; R. Raymond; W. F. Bodmer 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 French ⚖ 531 KB

Six new placental alkaline phosphatase monoclonal antibodies (MAbs) have been evaluated in order to select a potentially clinically useful antibody fragment for use in immunoxintigraphy or therapy. Initially, 3 antibodies were identified by trial pepsin digestion as likely to give satisfactory F(ab'