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Dose-dependent inhibition of theophylline metabolism by disulfiram in recovering alcoholics

✍ Scribed by Loi, Cho-Ming; Day, John D; Jue, Sandra G; Bush, Ernie D; Costello, Patrick; Dewey, Larry V; Vestal, Robert E

Book ID
109844674
Publisher
Nature Publishing Group
Year
1989
Tongue
English
Weight
847 KB
Volume
45
Category
Article
ISSN
0009-9236

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To establish the dose dependency of phospholipase A 2 (PLA 2 ) inhibition by the organophosphorus compound (OPC) paraoxon (POX), human platelet membranes were incubated after Ca 2+ removal (to inactivate the PLA 2 ) with 0.3, 1 and 3 g ml ؊1 POX for 5, 30 and 60 min each. The PLA 2 activity (pmol mg