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Dose-Dependent inhibition of complement in baboons by vaccinia virus complement control protein: implications in xenotransplantation

โœ Scribed by D. Kahn; S.A. Smith; G.J. Kotwal


Book ID
117233498
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
254 KB
Volume
35
Category
Article
ISSN
0041-1345

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Mapping of regions within the vaccinia v
โœ Scott A. Smith; R. Sreenivasan; Gunasekaran Krishnasamy; Ken W. Judge; Krishna H ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 636 KB

The vaccinia virus complement control protein (VCP) is involved in modulating the host inflammatory response by blocking both pathways of complement activity through its ability to bind C3b and C4b. Other activities arise from VCP's ability to strongly bind heparin. To map regions within VCP involve