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Dose-dependent effects of verapamil and nifedipine on in vivo platelet function in normal volunteers

✍ Scribed by K. Winther; C. M. Jespersen; B. Rydberg; G. Thamsborg; T. Hedner

Publisher
Springer
Year
1990
Tongue
English
Weight
265 KB
Volume
39
Category
Article
ISSN
0031-6970

No coin nor oath required. For personal study only.

✦ Synopsis

The effects of 1 week of treatment with low and moderate doses of verapamil or nifedipine upon platelet function has been studied in 12 healthy volunteers. The ex vivo platelet aggregation threshold for ADP or adrenaline was not altered by verapamil or nifedipine. The plasma concentrations of beta-thromboglobulin and platelet factor 4 were significantly reduced by low but not by moderate doses of verapamil and nifedipine. Low doses of verapamil and nifedipine inhibit in vivo platelet activity in healthy volunteers.

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