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Dose-dependent down-regulation of ß-adrenoceptors by isoproterenol in rat C6 glioma cells

✍ Scribed by Peter R. Bieck; David M. Duhl; Andrea Eiring; David D. Gillespie; D. Hal Manier; Fridolin Sulser


Book ID
113398351
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
410 KB
Volume
225
Category
Article
ISSN
0922-4106

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## Abstract Cultures of rat C6 rat glioma cells exhibit a diminished response to isoproterenol and forskolin after being treated with phorbol 12,13‐dibutyrate (PDbU). An IC50 for PDbU of 38±5 nM and 62±8 nM was observed in the isoproternol and forskolin response, respectively. Similarly, C6 culture