Dose-dependent change in tissue uptake of 17β-(16α-[125I]iodo)-estradiol in female rats: Application to external imaging of mammary carcinoma
✍ Scribed by Shinzaburo Noguchi; Hiroki Koyama; Syunichi Nakano
- Publisher
- Springer
- Year
- 1984
- Tongue
- English
- Weight
- 417 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0340-6997
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✦ Synopsis
Recently, many studies have drawn attention to the possibility of imaging estrogen-receptor-positive breast cancer with a high-affinity ligand such as 17 beta-(16 alpha-[125I]iodo)-estradiol (I-E2). We tried to determine the most suitable time and dose for imaging with this compound, using uteri of mature Sprague-Dawley rats. Although the uptake of I-E2 in the target organ (uterus) reached its peak 1 h after subcutaneous injection, the ratio of uptake in the target organ to that in nontarget organs (lung and muscle) peaked at 4 h. We also found that this ratio decreased as the dose increased. The clearest image was available 4 h after the dose meeting the minimum requirement for imaging was administered. An imaging trial of dimethylbenzanthracene (DMBA)-induced mammary carcinoma is also demonstrated.