Dose-dependent behavior of bioactive glass dissolution

✍ Scribed by Jones, Julian R. ;Sepulveda, Pilar ;Hench, Larry L.

• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 345 KB
• Volume: 58
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/jbm.10053

✦ Synopsis

Abstract

The effect of glass dosage (0.001 g ml^−1^ to 0.015 g ml^−1^) on the in vitro dynamic dissolution behavior of melt‐derived 45S5 and sol‐gel–derived 58S bioactive glasses, in simulated body fluid (SBF) at 37 °C, was evaluated. These glasses differ significantly in texture, especially the specific surface area and porosity, as a result of differences in manufacturing route. The concentrations of elements (Si, Ca, P, and Na) leached from the glasses into the dissolution medium, from 1 to 22 h, were evaluated with the use of induced coupled plasma analysis (ICP). The reacted powders were analyzed with the use of FTIR to observe the formation of a hydroxycarbonate apatite layer on the surface. The results show that the rate of HCA formation on both gel‐ and melt‐derived bioactive glass powders in vitro depends on the concentration of the powders in solution. This result must be taken into account when carrying out in vitro cell‐culture studies to simulate conditions in vivo and in experiments using extracts of the bioactive glass powders. © 2001 John Wiley & Sons, Inc. J Biomed Mater Res (Appl Biomater) 58: 720–726, 2001