Dose and scanning delay using USPIO for central nervous system macrophage imaging

✍ Scribed by Dousset, V

• Publisher: Springer
• Year: 1999
• Tongue: English
• Weight: 345 KB
• Volume: 8
• Category: Article
• ISSN: 0968-5243
• DOI: 10.1016/s1352-8661(99)00028-9

✦ Synopsis

Rationale and objecti6es: In experimental allergic encephalomyelitis (EAE), central nervous system (CNS) macrophage imaging is achievable by MRI using AMI-227 an ultra-small particle iron oxide contrast agent at a dose of 300 mmol/kg Fe. The objective was to test the feasibility at the human recommended dose of 45 mmol/kg Fe. Methods: Two groups of EAE rats were tested with AMI-227 using 45 and 300 mmol/kg Fe respectively. Following i.v. injection of AMI-227, they were scanned after a delay of 4-6 and 20-24 h. Results: With a high dose of AMI-227, all animals showed low signal intensity related to iron-loaded macrophages in the CNS. At low dose no abnormalities were found in the CNS. Furthermore, a delay of 4 -6 h failed to demonstrate abnormalities even at high dose. Conclusions: Dose, scanning delay after administration and blood half-life are major parameters for T2* CNS macrophage imaging.