Dopaminergic system in peripheral blood mononuclear cells in Parkinson's disease

✍ Scribed by Francesco E. Pontieri; Carlo Colosimo

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 178 KB
• Volume: 25
• Category: Article
• ISSN: 0885-3185
• DOI: 10.1002/mds.22742

✦ Synopsis

Lerner and Bagic 1 have to be congratulated for their hypothesis on PD pathogenesis. They suggest that the sequence of the brain changes in PD follows specific and repeatable patterns in all cases, as well as that a prion-like process underlies neurodegeneration. These ideas could explain several features of PD, such as the high prevalence of olfactory, autonomic, or sleep abnormalities. However, any pathogenic hypothesis should also explain: *TEMPO, Rasagiline Mesylate [TVP-1012] in Early Monotherapy for Parkinson's Disease Outpatients; PRESTO, Parkinson's Rasagiline: Efficacy and Safety in the Treatment of ''Off.''