Dopaminergic dysregulation in schizophrenia: A target for new drugs

✍ Scribed by Dr. Kenneth L. Davis; Michael Fiori; Bonnie M. Davis; Richard C. Mohs; Thomas B. Horvath; Michael Davidson

• Book ID: 102817492
• Publisher: John Wiley and Sons
• Year: 1986
• Tongue: English
• Weight: 816 KB
• Volume: 9
• Category: Article
• ISSN: 0272-4391
• DOI: 10.1002/ddr.430090109

✦ Synopsis

The dopamine hypothesis postulates that at least some schizophrenic symptoms are a reflection of central nervous system hyperdopaminergia. The evidence for this model is briefly reviewed and its shortcomings highlighted. The dysregulation hypothesis of schizophrenia should be a useful reformulation. Rather than conceptualizing a static hyperdopaminergic state, schizophrenia might be better understood as a reflection of a relative failure of dopaminergic regulation. Evidence for such dysregulation is examined and possible mechanisms are presented. Avenues of future drug research are proposed.