Dopaminergic drugs reverse the impairment of radial-arm maze performance caused by lesions involving the cholinergic medial pathway

Radial-arm maze performance in rats is i

Radial-arm maze performance in rats is impaired by a combination of nicotinic-cholinergic and D2dopaminergic antagonist drugs

✍ Susan R. McGurk; Edward D. Levin; Larry L. Butcher 📂 Article 📅 1989 🏛 Springer 🌐 English ⚖ 344 KB

Performance on the radial-arm maze depends on the integrity of both cholinergic and dopaminergic systems. We have previously found that administration of either the nicotinic-cholinergic antagonist, mecamylamine, or the muscarinic-cholinergic antagonist, scopolamine, impairs choice accuracy in the r