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Dopaminergic D-1 receptors: essential role in morphine-induced hypermotility

โœ Scribed by R. Longoni; L. Spina; G. Chiara

Publisher
Springer
Year
1987
Tongue
English
Weight
189 KB
Volume
93
Category
Article
ISSN
0033-3158

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โœฆ Synopsis

Administration of morphine HC1 (20 mg/kg SC) to male C57BI/6 mice evoked hypermotility. Pretreatment with low doses of the specific D-1 antagonist SCH 23390 (0.006, 0.012, 0.025 mg/kg SC) dose-dependently inhibited morphine-evoked hypermotility. The results suggest that dopamine is the essential mediator of opiate hypermotility and indicate that D-1 receptors play an important role in this effect.

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