Dopamine β-hydroxylase −1021C>T association and Parkinson's disease
✍ Scribed by Owen A. Ross; Michael G. Heckman; Alexandra I. Soto; Nancy N. Diehl; Kristoffer Haugarvoll; Carles Vilariño-Güell; Jan O. Aasly; Sigrid Sando; J. Mark Gibson; Timothy Lynch; Anna Krygowska-Wajs; Grzegorz Opala; Maria Barcikowska; Krzysztof Czyzewski; Ryan J. Uitti; Zbigniew K. Wszolek; Matthew J. Farrer
- Book ID
- 116820561
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 106 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1353-8020
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## Abstract A functional −1021C → T polymorphism in the dopamine β‐hydroxylase gene has been demonstrated to regulate plasma DBH activity. We report that individuals with genetically determined low serum DBH activity (genotype T/T) have protection against Parkinson's disease (__p__ = 0.01). In part