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Dopamine β-hydroxylase −1021C>T association and Parkinson's disease

✍ Scribed by Owen A. Ross; Michael G. Heckman; Alexandra I. Soto; Nancy N. Diehl; Kristoffer Haugarvoll; Carles Vilariño-Güell; Jan O. Aasly; Sigrid Sando; J. Mark Gibson; Timothy Lynch; Anna Krygowska-Wajs; Grzegorz Opala; Maria Barcikowska; Krzysztof Czyzewski; Ryan J. Uitti; Zbigniew K. Wszolek; Matthew J. Farrer


Book ID
116820561
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
106 KB
Volume
14
Category
Article
ISSN
1353-8020

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A functional polymorphism regulating dop
✍ Daniel G. Healy; Patrick M. Abou-Sleiman; Tetsutaro Ozawa; Andrew J. Lees; Kaila 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 125 KB

## Abstract A functional −1021C → T polymorphism in the dopamine β‐hydroxylase gene has been demonstrated to regulate plasma DBH activity. We report that individuals with genetically determined low serum DBH activity (genotype T/T) have protection against Parkinson's disease (__p__ = 0.01). In part