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Dopamine-transporter occupancy after intravenous doses of cocaine and methylphenidate in mice and humans

โœ Scribed by S. J. Gatley; Nora D. Volkow; Andrew N. Gifford; Joanna S. Fowler; Stephen L. Dewey; Yu-Shin Ding; Jean Logan


Book ID
105885066
Publisher
Springer
Year
1999
Tongue
English
Weight
71 KB
Volume
146
Category
Article
ISSN
0033-3158

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Concentration and occupancy of dopamine
โœ Jean Logan; Nora D. Volkow; Joanna S. Fowler; Gene-Jack Wang; Marian W. Fischman ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 126 KB

The concentration (Bmax) of the dopamine transporter (DAT) and the maximum and effective occupancies by cocaine doses of 0.1 mg/kg or 0.05 mg/kg were measured in the striatum of cocaine abusers (n ฯญ 12) by using [ 11 C]cocaine as a radiotracer for the DAT and positron emission tomography (PET). Two