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Dopamine transporter loss and clinical changes in MPTP-lesioned primates

✍ Scribed by Jamie L Eberling; Krzysztof S Bankiewicz; Phillip Pivirotto; John Bringas; Karen Chen; David P Nowotnik; Joseph P Steiner; Thomas F Budinger; William J Jagust

Book ID: 114004995
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 97 KB
Volume: 832
Category: Article
ISSN: 0006-8993
DOI: 10.1016/s0006-8993(99)01491-2

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## Abstract The neurotoxicant 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) provides an excellent opportunity to study repair and response to injury in the basal ganglia. Administration to mammals leads to the destruction of nigrostriatal dopaminergic neurons and depletion of striatal dopamin