Dopamine transporter gene polymorphism and psychiatric symptoms seen in schizophrenic patients at their first episode
✍ Scribed by Inada, Toshiya; Sugita, Tetsuyoshi; Dobashi, Izumi; Inagaki, Ataru; Kitao, Yoshie; Matsuda, Genichi; Kato, Shingo; Takano, Toshiya; Yagi, Gohei; Asai, Masahiro
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 323 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0148-7299
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✦ Synopsis
To investigate the possible role of the dopamine transporter (DAT) gene in determining the phenotype in human subjects, allele frequencies for the 40-bp variable number of tandem repeats (VNTR) polymorphism at this site were compared between 117 Japanese normal controls and 118 schizophrenic patients, including six subgroups: earlyonset, those with a family history, and those suffering from one of the following psychiatric symptoms at their first episode: delusion and hallucination; disorganization; bizarre behavior; and negative symptoms. No significant differences were observed between the group as a whole or any subgroup of schizophrenic patients and controls. The results indicate that VNTR polymorphism in the DAT gene is unlikely to be a major contributor to any of the psychiatric parameters examined in the present population of schizophrenic subjects.