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Dopamine transporter binding in Gilles de la Tourette syndrome: a [123I]FP-CIT/SPECT study

โœ Scribed by J. Serra-Mestres; H. A. Ring; D. C. Costa; S. Gacinovic; Z. Walker; A. J. Lees; M. M. Robertson; M. R. Trimble

Book ID
110724114
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
109 KB
Volume
109
Category
Article
ISSN
0001-690X

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## Abstract Neuropsychiatric symptoms are frequent in dementia with Lewy bodies (DLB). Dopamine transporter (DAT) imaging with ^123^Iโ€labeled ligand __N__โ€ฮดโ€(fluoropropyl)โ€2ฮฒโ€carbomethoxyโ€3ฮฒโ€(4โ€iodophenyl)tropene (^123^Iโ€FPโ€CIT), which reliably measures midbrain dopaminergic dysfunction, has provid

[123I]FP-CIT binds to the dopamine trans
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[123I]FP-CIT (N-omega-fluoropropyl-2 beta-carbomethoxy-3 beta-(4-iodophenyl)-tropane), a radioiodinated cocaine analogue, was evaluated as an agent for the in vivo labeling of dopamine (DA) transporters by biodistribution studies in rats and by single photon emission computed tomography (SPECT) stud