Intracerebral microdialysis was used to investigate the effects of local application of L-glutamate, N-methyl-D-aspartate, and the glutamate uptake inhibitor l-trans-pyrrolidine-2,4-dicarboxylic acid (PDC) in the nucleus accumbens (NAc) on extracellular dopamine (DA) concentrations. The effects of l
β¦ LIBER β¦
Dopamine regulation of extracellular glutamate in the nucleus accumbens
β Scribed by Peter W Kalivas; Patricia Duffy
- Book ID
- 114002778
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 193 KB
- Volume
- 761
- Category
- Article
- ISSN
- 0006-8993
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In the present study, we have characterized the neuropharmacological regulation of nicotine-induced increases in extracellular nucleus accumbens glutamate levels. Sprague-Dawley rats were stereotaxically implanted with 2 mm microdialysis probes in the nucleus accumbens and on the following day in vi