✦ LIBER ✦

Dopamine receptors in the basal ganglia: Relevance to parkinson's disease

✍ Scribed by Dr. Philip G. Strange

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 735 KB
Volume: 8
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.870080303

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✦ Synopsis

Abstract

At least five receptors for dopamine (D~1~–D~5~) have been recognised from molecular biological studies, and their pharmacological properties and brain localisations have been determined. The D~1~ and D~2~ subtypes are the principal subtypes in brain, and their cellular localisations in the caudate nucleus and putamen have been determined. With recent advances in the understanding of basal ganglia neuronal function, these localisation data enable insights into the mode of action of drugs used at present and in the futue to treat Parkinson's disease.

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