Dopamine-mediated circling behaviour does not involve the nigro-tectal pathway

✍ Scribed by C. Reavill; N. Leigh; P. Jenner; C. D. Marsden

• Book ID: 104677199
• Publisher: Springer-Verlag
• Year: 1979
• Tongue: English
• Weight: 514 KB
• Volume: 37
• Category: Article
• ISSN: 0014-4819
• DOI: 10.1007/bf00237716

✦ Synopsis

Extensive unilateral or bilateral electrolytic ablation of the rat superior colliculus failed to reduce apomorphine- or amphetamine-induced rotation in animals with a unilateral 6-hydroxydopamine lesion of one nigro-striatal dopaminergic pathway. These findings suggest that a nigro-tectal pathway does not play a crucial role in mediating the circling response caused by striatal dopamine receptor stimulation. However, electrolytic lesions of the dorsal tegmental decussation reduced apomorphine- but not amphetamine-induced rotation in such animals, perhaps by sectioning some commissural pathway between the two nigro-striatal systems.