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Dopamine-mediated behaviour and 3H-spiperone binding to striatal membranes in rats after nine months haloperidol administration

✍ Scribed by F. Owen; A.J. Cross; J.L. Waddington; M. Poulter; S.J. Gamble; T.J. Crow


Book ID
118938994
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
221 KB
Volume
26
Category
Article
ISSN
0024-3205

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Methyl mercury inhibits dopamine (DA) and serotonin (5-HT) uptake by brain synaptosomes and decreases antagonist binding to striatal dopaminergic D2 receptors in vitro. To assess the effects in vivo, adult rats were given methyl mercury, either as a single dose (10 mg/kg by gavage) or a cumulative t