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Dopamine induces apoptosis in cultured rat striatal neurons; possible mechanism of D2-dopamine receptor neuron loss during aging

✍ Scribed by T. Shinkai; L. Zhang; S.A. Mathias; G.S. Roth

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 182 KB
Volume: 47
Category: Article
ISSN: 0360-4012
DOI: 10.1002/(sici)1097-4547(19970215)47:4<393::aid-jnr4>3.0.co;2-9

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✦ Synopsis

We examined D 2 -dopamine receptor containing neurons in cultures of neonatal rat striatum for apoptosis following dopamine treatment. Exposure to cultures to micromolar concentrations of dopamine resulted in 60-70% killing of D 2 -dopamine receptor neurons within 24 hr. We also utilized a double labeling procedure to determine that treatment with dopamine induced apoptosis in D 2 -dopamine receptor containing neurons. These results suggest that loss of D 2dopamine receptor containing neurons during aging could be due to an apoptotic effect of dopamine. J.

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