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Dopamine imaging markers and predictive mathematical models for progressive degeneration in Parkinson's disease

✍ Scribed by A.L. Brownell; B.G. Jenkins; O. Isacson


Book ID
117576324
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
964 KB
Volume
53
Category
Article
ISSN
0753-3322

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## Abstract 6‐Hydroxydopamine (6‐OHDA), a neurotoxin that causes the death of dopamine (DA) neurons, is commonly used to produce experimental models of Parkinson's disease (PD) in rodents. In the rat model of PD first described by Sauer and Oertel, DA neurons progressively die over several weeks fo