Sodium salicylate was infused through a microdialysis probe placed in the striatum of anesthetized rats in order to assay the formation of hydroxyl radical ( . OH) in the extracellular fluid in vivo. In addition to causing sustained dopamine release, intrastriatal infusion of the 2'-methyl analog of
Dopamine efflux by MPTP and hydroxyl radical generation
โ Scribed by T. Obata
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 114 KB
- Volume
- 109
- Category
- Article
- ISSN
- 1435-1463
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๐ SIMILAR VOLUMES
Hydroxylation of l-phenylalanine (Phe) by hydroxyl radical (\*OH) yields 4-, 3-, and 2-hydroxyl-Phe (para-, meta-, and ortho-tyrosine, respectively). Phe derivative measurements have been employed to detect \*OH formation in cells and tissues, however, the specificity of this assay is limited since
## Abstract Reactive oxygen species, probably hydroxyl radicals (OHยท), have been suggested to be generated during arachidonic acid (AA) metabolism and, once released, these species can modify the rate and extent of various reactions involved in AA metabolism. We have studied this phenomenon in wash