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Dopamine D4 receptor variants in unrelated schizophrenic cases and controls

✍ Scribed by Sommer, Steve S. ;Lind, Tammy J. ;Heston, Leonard L. ;Sobell, Janet L.


Book ID
101444426
Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
437 KB
Volume
48
Category
Article
ISSN
0148-7299

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Variation in the number of tandem repeats of a 48 base pair (bp) unit was found in the gene of the dopamine D4 receptor (DRD4). The number of repetitions of the 48bp unit was shown to influence the binding of clozapine, which suggests that different alleles may function differently in vivo and affec

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## Abstract We have examined the hypothesis that a variable number of tandem repeats in the third cytoplasmic loop of the dopamine D4 receptor influences clinical response to clozapine using a sample of 189 schizophrenic patients. Alleles of the 48‐bp repeat, which range from two to ten copies in t