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Dopamine D4 receptor gene variants and schizophrenia

✍ Scribed by Kennedy, J.L.; Van Tol, H.H.M.; Petronis, A.; Sidenberg, D.G.; Macciardi, F.; Honer, W.G.; Bassett, A.S.


Book ID
122651949
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
118 KB
Volume
9
Category
Article
ISSN
0920-9964

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The dopamine D4 receptor is of major interest in schizophrenia research due to its high affinity for the atypical neuroleptic clozapine and a high degree of variability in the receptor gene (DRD4). Although several genetic linkage analyses performed on schizophrenia multiplex families from different