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Dopamine D2 receptor knock-out mice are insensitive to the hypolocomotor and hypothermic effects of dopamine D2/D3 receptor agonists

✍ Scribed by D Boulay; R Depoortere; Gh Perrault; E Borrelli; D.J Sanger


Book ID
117188318
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
132 KB
Volume
38
Category
Article
ISSN
0028-3908

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L-dopa remains the most common treatment for Parkinson's disease. However, there is considerable interest in D3/D2 receptor agonists such as the novel agent S32504, since they exert antiparkinsonian properties in the absence of dyskinesia. An important question concerns the roles of D2 vs. D3 recept