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Dopamine D1 receptors and age differences in brain activation during working memory

✍ Scribed by Lars Bäckman; Sari Karlsson; Håkan Fischer; Per Karlsson; Yvonne Brehmer; Anna Rieckmann; Stuart W.S. MacDonald; Lars Farde; Lars Nyberg


Book ID
116781554
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
568 KB
Volume
32
Category
Article
ISSN
0197-4580

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Radioligand binding studies in animals have demonstrated age-related loss of dopamine receptors in the caudate and putamen. In humans, while age-related declines in dopamine D2 receptors have been consistently reported, the effects of ageing on D1 receptors have been controversial. We used positron