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Dopamine and acetylcholine neurones in striatal and limbic structures: Effect of neuroleptic drugs

✍ Scribed by K.G. Lloyd; H. Stadler; G. Bartholini


Book ID
115771951
Publisher
Elsevier Science
Year
1974
Tongue
English
Weight
163 KB
Volume
23
Category
Article
ISSN
0006-2952

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Clozapine and molindone administered to mice for 21 days did not elevate the density of striatal 3H-spiperone binding sites at doses clinically equivalent to 1.5 mg/kg haloperidol, which elevated binding by 29%. Thioridazine (25 mg/kg) elevated binding by 25%. It appears that clinically equivalent d