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Dopa-responsive pseudo-orthostatic tremor in parkinsonism

✍ Scribed by Astrid Thomas; Laura Bonanni; Angelo Antonini; Paolo Barone; Marco Onofrj

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 139 KB
Volume: 22
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.21621

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✦ Synopsis

Abstract

In four patients an inabilitating standing tremor appeared years before that parkinsonian symptoms were evidenced. This tremor was refractory to gabapentin and dramatically responded to Levodopa administration. Its dominant frequency was 6.2 to 6.9 Hz with sporadic subharmonics at 8 to 18 Hz. Three patients were affected by different genetic mutations (Park 2, Park 6, mtDNA deletion) in one no genetic or metabolic alterations could be evidenced. All patients had dopamine transporter abnormalities. We suggest that the term “Pseudo‐Orthostatic Tremor” could be used to define this Dopa responsive, 6 to 7 Hz standing tremor. © 2007 Movement Disorder Society

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